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In an unprecedented move, The Home of Rest for Horses has made two
awards for clinical evidence this year. The awards are presented at this week's British
Equine Veterinary Association conference.
The peer review panel of Professor Stephen May, past chairman of the Home's Scientific
Sub-Committee, Celia Marr of Rossdale Veterinary Practice, Newmarket; Alistair Barr of
Bristol University Veterinary School, Josh Slater of the Royal Veterinary College and
Ian Camm of Bushey Equine Vets, were unable to separate papers on Oral hyaluronan gel
and risk factors for colic.
BJ Bergin, SW Pierce, and LR Bramlage, all then of the Rood and Riddle Equine Hospital
in Lexington, Kentucky and A Stromberg of the Department of Statistics, University of
Kentucky, submitted the paper "Oral Hyaluronan Gel Reduces Postoperative Tarsocrural
Effusion in the Yearling Thoroughbred".
It reported their research into the efficacy of oral administration of hyaluronic acid
(HA) to treat joint disease following arthroscopic surgery of osteochondritis dissecans
(OCD) of the tarsocrural joint of yearling thoroughbreds. Only animals showing mild or
no synovial effusion pre-surgery were selected for study. 57 joints were included from 48
horses, with 24 treated with 100g of HA orally for 30 days post-operatively and 24 treated
with a placebo.
The trial confirmed anecdotal reports of the efficacy of HA administered orally in reducing
joint effusion postoperatively.
MS Andersen, L Clark, SJ Dyson and JR Newton of the Animal Health Trust, Newmarket, submitted
their clinical evidence paper on "Risk factors for colic in horses after general anaesthesia for
MRI or nonabdominal surgery: absence of evidence of effect from perianaesthetic morphine".
Records of 553 anaesthetic and clinical records of 500
horses anaesthetised at the AHT were analysed. This
showed that 7.1% of surgical cases developed colic post-anaesthesia
compared with only 1.5% of animals subjected to magnetic
resonance imagery (MRI) scanning. It also showed a significantly
increased risk of colic associated with premedication
with romifidine, maintenance of anaesthesia with isoflurane
and the administration of benzyl penicillin and/or ceftiofur.
The risk lessened with longer duration of anaesthesia
and sedation within two days of anaesthesia. The use
of perianaesthetic morphine did not contribute to any
increase in risk.
The researchers at the AHT, while recommending a wider study of the issue, concluded that the
potential benefits of reducing intraoperative and post operative pain must be weighed against
any perceived risk of colic.
"Following our independent review of the papers submitted for the award, we ended up with a tie
between these two papers and, having consulted about the possibility of breaking the first-place
tie, decided unanimously that joint winners would be appropriate," said Prof May.
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